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Methotrexate injection is also used along with rest, physical therapy and sometimes other medications to treat severe active rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that cannot be controlled by certain other medications.

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Instruct patient to report signs and symptoms of allergic response and other adverse reactions, such as rash, easy bruising, bleeding, severe GI problems, or difficulty breathing.

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Refrigeration is not required for commercially prepared sealed solutions, but the solution should be used immediately after opening and the unused portions should be discarded.

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NSAIDs (non-steriodal anti-inflammatory drugs) is included in the Step 1 of the World Health organization analgesic ladder.

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